Remedy The remedy of overdosage with promethazine and phenylephrine is essentially symptomatic and supportive. Only in cases of maximum overdosage or personal sensitivity do vital signals which includes respiration, pulse, hypertension, temperature, and EKG must be monitored. Activated charcoal orally or by lavage might be specified, or sodium or magnesium sulfate orally being a cathartic.
Promethazine is perfectly absorbed through the gastrointestinal tract. Medical consequences are obvious inside twenty minutes soon after oral administration and usually last four to 6 several hours, While They might persist so long as 12 hrs.
It can be freely soluble in drinking water and Alcoholic beverages. Phenylephrine hydrochloride is subject matter to oxidation and has to be protected from gentle and air. It has a molecular fat of 203.67, a molecular formula of C9H13NO2 • HCl, and the following structural system:
Promethazine and phenylephrine ought to be used all through pregnancy only if the prospective advantage justifies the probable danger towards the fetus.
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Given that recurrences of NMS happen to be documented with phenothiazines, the reintroduction of promethazine HCl needs to be carefully regarded as.
Adhering to oral administration or topical application of phenylephrine on the mucosa, constriction of blood vessels while in the nasal mucosa relieves nasal congestion related to allergy or head colds.
Decrease Seizure Threshold: Promethazine may perhaps reduced seizure threshold. It should be used with caution in persons with seizure Ailments or in individuals who will be making use of concomitant prescription drugs, which include narcotics or local anesthetics, which may also have an impact on seizure threshold.
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Recognized for its strong cough-suppressing and antihistamine results, this medication is prescribed to relieve signs or symptoms for example persistent cough, throat discomfort, and higher respiratory tract discomfort.
Men with symptomatic, benign prostatic hypertrophy can practical experience urinary retention when given oral nasal decongestants.
Although Akorn Cough Syrup is often thought to be safe for brief-phrase use, lots of people could have adverse consequences like sleepiness, nausea, or dizziness. This medication need to be employed diligently, and it ought to not be taken with alcohol or other sedatives.